A new nitrogenous metabolite with a p-terphenyl core, sarcodonin (3), has been isolated from fruiting bodies of the basidiomycete Sarcodon leucopus. The structure of 3 was determined through a careful study of its peracetate 4, by use of an array of spectroscopic techniques (including N-15 NMR, gradient-enhanced, and reverse-detected 2D NMR experiments) and chemical degradation. ROESY data and molecular mechanics (MM+) calculations led to assignment of the absolute configuration of 4. Compound 3 exhibited moderate cytotoxicity against KB and P-388 tumor cell cultures.
An unusual nitrogenous terphenyl derivative from fruiting bodies of the basidiomycete Sarcodon leucopus
TRINGALI, Corrado
2000-01-01
Abstract
A new nitrogenous metabolite with a p-terphenyl core, sarcodonin (3), has been isolated from fruiting bodies of the basidiomycete Sarcodon leucopus. The structure of 3 was determined through a careful study of its peracetate 4, by use of an array of spectroscopic techniques (including N-15 NMR, gradient-enhanced, and reverse-detected 2D NMR experiments) and chemical degradation. ROESY data and molecular mechanics (MM+) calculations led to assignment of the absolute configuration of 4. Compound 3 exhibited moderate cytotoxicity against KB and P-388 tumor cell cultures.File in questo prodotto:
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