HMGB1 levels in children with atopic eczema/dermatitis syndrome (AEDS)

Atopic eczema/dermatitis syndrome (AEDS) is a chronic relapsing-remitting inflammatory skin disorder beginning usually in early childhood, characterized by a skin barrier dysfunction resulting epidermal damage and altered permeability to allergensand microbes. Depending on whether there is an association with or withoutimmunoglobulin (Ig) E sensitization, AEDS maybe defined as atopic (aAEDS) or non-atopic (naAEDS), respectively. In this study the Authorsanalyzed the HMGB1 levels in both patients with naAEDS and patients with aAEDS, the relationship between serum HMGB1 levels and clinical severity of the disease, and finally, the HMGB1levels in different allergic phenotypes such as aAEDSplus allergic sensitization, aAEDs plus rhinitis, aAEDS plus asthma, and aAEDS plus rhinitis and asthma. Moreovers the Authors investigated the relationship between HMGB1 and IL17/IL13 axis and IL10. They conclude that HMGB1 may offera sensitive bombarder for AEDS in children, which is well correlated with the degree of disease severity's well switch more severe comorbidities.