The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.
|Titolo:||Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||1.1 Articolo in rivista|