Long term clinical course of Tourette syndrome.

Background: Recent studies using cluster analysis and factor analysis have suggested that Tourette Syndrome (TS) should no longer be considered a unitary condition. Material and methods: We retrospectively studied the long term clinical course of 100 TS patients. The patients were assessed at the onset and after 10years follow-up to evaluate the severity of tic, the Obsessive Compulsive Disorder (OCD), the Attention Deficit Hyperactivity Disorder (ADHD) and the presence of anxiety and depression, rage attacks, self injuries behavior. Moreover at the follow-up they completed an evaluation scale on quality of life to assess the impairment in everyday life after 10years of illness. Results: The "pure TS" clinical group (38 subjects) showed after 10years follow-up that 58% carried on with the same clinical phenotype, whereas 42% changed in "TS+OCD" phenotype. Fifty-five percentage required pharmacological treatment. All the "TS+ADHD" clinical group (48 subjects) showed after 10years follow-up a different clinical phenotype: 62% "TS pure" phenotype, 35% "TS+OCD" phenotype, 2% "TS+ADHD+OCD" phenotype. Sixty-five percentage of the subject required pharmacological treatment. The "TS+ADHD+OCD" clinical group (14 subjects) after 10years follow-up showed that 14% carried on with the same clinical phenotype, whereas 8.3% presented "TS pure" phenotype and 92% presented "TS+OCD" phenotype. Seventy-one percentage were in need of therapy. With regards to quality of life, patients presented widespread impairment correlated to the presence of comorbid conditions. Conclusion: Our findings suggest that pure TS has quite a good long-term clinical course. By contrast, those who presented comorbid condition at the onset showed a more severe prognosis