Elevated eye pressure is the main risk factor for glaucoma, and intraocular pressure rises when the balance between aqueous humor formation and outflow resistance is compromised. In a normal eye there is a precise tune of aqueous outflow under the fine control of ciliary body and trabecular meshwork. Current pharmacological therapies for lowering the intraocular pressure in glaucoma include increasing aqueous humor outflow and suppression of aqueous humor production. However, most of antiglaucoma drugs currently on the market do not target the trabecular meshwork that represents the site of the pathology. This review focuses on pharmacological management of ocular hypertension with a particular attention to the future pharmacotherapy scenario.

Pharmacological management of ocular hypertension: current approaches and future prospective

BUCOLO, CLAUDIO;SALOMONE, Salvatore;DRAGO, Filippo;REIBALDI, MICHELE;LONGO, ANTONIO;UVA, Maurizio Giacinto
2013-01-01

Abstract

Elevated eye pressure is the main risk factor for glaucoma, and intraocular pressure rises when the balance between aqueous humor formation and outflow resistance is compromised. In a normal eye there is a precise tune of aqueous outflow under the fine control of ciliary body and trabecular meshwork. Current pharmacological therapies for lowering the intraocular pressure in glaucoma include increasing aqueous humor outflow and suppression of aqueous humor production. However, most of antiglaucoma drugs currently on the market do not target the trabecular meshwork that represents the site of the pathology. This review focuses on pharmacological management of ocular hypertension with a particular attention to the future pharmacotherapy scenario.
ocular pharmacology; glaucoma; intraocular pressure
File in questo prodotto:
File Dimensione Formato  
Pharmacological management of ocular hypertension.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Dimensione 252.79 kB
Formato Adobe PDF
252.79 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/41553
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 52
social impact