The synthesis of 4′-α–C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells.
Titolo: | 4′-α-C-Branched N,O-nucleosides: synthesis and biological properties |
Autori interni: | |
Data di pubblicazione: | 2004 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.11769/4235 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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