The synthesis of 4′-α–C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells.
|Titolo:||4′-α-C-Branched N,O-nucleosides: synthesis and biological properties|
|Data di pubblicazione:||2004|
|Citazione:||4′-α-C-Branched N,O-nucleosides: synthesis and biological properties / CHIACCHIO U; GENOVESE F; IANNAZZO D; PIPERNO A; QUADRELLI P; CORSARO A; ROMEO R; VALVERI V; MASTINO A. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 12(2004), pp. 3903-3909.|
|Appare nelle tipologie:||1.1 Articolo in rivista|