Recent studies suggest that subjects with hypothyroidism under therapy with L-T4 might develop oxidative stress. The aim of this study was to test a redox-balance modulator, FPP, together with subclinical (SH) or mild hypothyroidism (MH) treatment in view of biochemical changes. 60 females treated for SH-MH were divided into two matched groups and received either FPP 3gr 1 sachet t.i.d. or placebo for 3 months. A significant baseline increase of all oxidative markers was observed in SH-MH (p<0.05 vs control) and even more under T4 treatment (p<0.05). FPP caused a normalization of redox markers (p<0.01 vs placebo). Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress while a redox-modulator therapy is advisable, given the long-lasting treatment in such cases.
|Titolo:||The Hidden Phenomenon of Oxidative Stress During Treatment of Subclinical-Mild Hypothyroidism:A Protective Nutraceutical Intervention|
|Data di pubblicazione:||2014|
|Citazione:||The Hidden Phenomenon of Oxidative Stress During Treatment of Subclinical-Mild Hypothyroidism:A Protective Nutraceutical Intervention / Tomella, C; Catanzaro, Roberto; Illuzzi, N; Cabeca, A; Zerbinati, N; Celep, G; Milazzo, M; Sapienza, C; Italia, A; Lorenzetti, A; Marotta, F.. - In: REJUVENATION RESEARCH. - ISSN 1549-1684. - Sep 19(2014).|
|Appare nelle tipologie:||1.1 Articolo in rivista|