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EnglishLabour and modes of delivery can influence the plasma levels of stress hormones and cytokines involved in pathophysiologic cascade, potentially damaging brain development of the newborn. This prospective observational, single-centre, case-control, non-profit study aimed to detect potential differences in foetal well-being such as stress neuroendocrine responses. Quantitative determinations of the stress markers interleukin (IL)-1b, IL-8, and b-endorphin were compared between the control group and the epidural analgesia group. We found higher IL1-b levels but lower IL-8 and b-endorphin levels in the epidural analgesia group than in the control group. No significant inter-group differences were observed for any parameters. Our findings demonstrate that epidural analgesia for pain relief during labour does not result in significant differences in blood stress response markers.
| Titolo: | Epidural analgesia during labour and stress markers in the newborn |
| Autori interni: | |
| Data di pubblicazione: | 2020 |
| Rivista: | |
| Abstract: | Labour and modes of delivery can influence the plasma levels of stress hormones and cytokines involved in pathophysiologic cascade, potentially damaging brain development of the newborn. This prospective observational, single-centre, case-control, non-profit study aimed to detect potential differences in foetal well-being such as stress neuroendocrine responses. Quantitative determinations of the stress markers interleukin (IL)-1b, IL-8, and b-endorphin were compared between the control group and the epidural analgesia group. We found higher IL1-b levels but lower IL-8 and b-endorphin levels in the epidural analgesia group than in the control group. No significant inter-group differences were observed for any parameters. Our findings demonstrate that epidural analgesia for pain relief during labour does not result in significant differences in blood stress response markers. |
| Handle: | http://hdl.handle.net/20.500.11769/437663 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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