Sodium [N-(1,5-dimethyl-3-oxo-2-phenylpyrazolin-4-yl)-N-methylamino] methanesulfonate (dipyrone) cannot be detected as such in biological fluids since absorption is preceded by hydrolysis to 4 - methylaminoantipyrine, which is actually absorbed and further metabolized. In the present work standardized TLC R(f) values and gas chromatographic retention indices for the four main urinary metabolites of dipyrone were determined. Inclusion of these parameters in the principal component analysis ''scores plot'' allows dipyrone to be included as a possible candidate in the not oriented search for unknow drug assumption in cases of over-dose intoxication or poisoning.
DETERMINATION OF THE CHROMATOGRAPHIC PATTERN FOR THE IDENTIFICATION OF DIPYRONE URINARY METABOLITES
FOTI, Salvatore;MUSUMARRA, Giuseppe;SALETTI, Rosaria;
1991-01-01
Abstract
Sodium [N-(1,5-dimethyl-3-oxo-2-phenylpyrazolin-4-yl)-N-methylamino] methanesulfonate (dipyrone) cannot be detected as such in biological fluids since absorption is preceded by hydrolysis to 4 - methylaminoantipyrine, which is actually absorbed and further metabolized. In the present work standardized TLC R(f) values and gas chromatographic retention indices for the four main urinary metabolites of dipyrone were determined. Inclusion of these parameters in the principal component analysis ''scores plot'' allows dipyrone to be included as a possible candidate in the not oriented search for unknow drug assumption in cases of over-dose intoxication or poisoning.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
