The photochemistry of fenbufen, gamma -oxo-[1,1'-biphenyl]-4-butanoic acid (FB), has been investigated in homogeneous solutions and in micellar environments. The photochemical and photophysical properties of the drug are mediated by its lowest excited triplet states. The presence of a low-lying pi,pi* triplet is responsible for the inefficient Norrish Type I photocleavage, whereas an upper n,pi* triplet promotes a large intersystem crossing yield. FB interacts with both anionic and cationic micelles. The different binding mode of the drug with the microheterogeneous environments can significantly change its photoreactivity. These changes are rationalized on the basis of "micellar cage effects''. RI Sortino, Salvatore/E-4684-2011
On the photophysical and photochemical behavior of fenbufen: a study in homogeneous media and micellar environments
SORTINO, Salvatore;
2001-01-01
Abstract
The photochemistry of fenbufen, gamma -oxo-[1,1'-biphenyl]-4-butanoic acid (FB), has been investigated in homogeneous solutions and in micellar environments. The photochemical and photophysical properties of the drug are mediated by its lowest excited triplet states. The presence of a low-lying pi,pi* triplet is responsible for the inefficient Norrish Type I photocleavage, whereas an upper n,pi* triplet promotes a large intersystem crossing yield. FB interacts with both anionic and cationic micelles. The different binding mode of the drug with the microheterogeneous environments can significantly change its photoreactivity. These changes are rationalized on the basis of "micellar cage effects''. RI Sortino, Salvatore/E-4684-2011I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
