IMS:Oxidative stress increase is a key event for development of sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the influence of genetic variants in antioxidant enzymes on oxidative stress development in SRIs.MAIN METHODS:Glutathione peroxidase (GPx1) rs1800668 genotype, as well as glutathione, ubiquinone, and DNA damage were assessed in 34 SRI patients and 36 healthy subjects.KEY FINDINGS:Total glutathione, reduced/oxidized glutathione, and ubiquinone were significantly decreased in cases compared with controls, while DNA fragmentation was significantly increased in patients. However, these differences were not associated to GPx1 genetic background.SIGNIFICANCE:GPx1 rs1800668 polymorphism does not play a major role in SRI-related oxidative stress development.
Assessment of glutathione peroxidase-1 polymorphisms, oxidative stress and DNA damage in sensitivity-related illnesses.
RENIS, Marcella;
2016-01-01
Abstract
IMS:Oxidative stress increase is a key event for development of sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the influence of genetic variants in antioxidant enzymes on oxidative stress development in SRIs.MAIN METHODS:Glutathione peroxidase (GPx1) rs1800668 genotype, as well as glutathione, ubiquinone, and DNA damage were assessed in 34 SRI patients and 36 healthy subjects.KEY FINDINGS:Total glutathione, reduced/oxidized glutathione, and ubiquinone were significantly decreased in cases compared with controls, while DNA fragmentation was significantly increased in patients. However, these differences were not associated to GPx1 genetic background.SIGNIFICANCE:GPx1 rs1800668 polymorphism does not play a major role in SRI-related oxidative stress development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
