Background: Multiple differences between males and females are reported both in physiological and pathophysiological conditions. Aims: To test the hypothesis that gender could influence the motor and cognitive development in children with cerebral palsy (CP). Methods: Prospective, cross-sectional. One hundred seventy one children with CP (98 males and 73 females) were evaluated for motor (Gross Motor Function Measure, Gross Motor Function Classification System) and cognitive (Bayley II, Wechsler Scales) functions. Eightyfour of them were assessed before and other eighty-seven children after 4 years of age. Results: No gender-related differences were observed in children with diplegia or quadriplegia, both for motor and cognitive functions. On the contrary, females with hemiplegia scored significantly better (P < 0.01) in cognitive functions and in the dimension D (standing) of the Gross Motor Function Measure, under the age of 4 years. These differences were not observed after this age. Conclusions: In this study we point out that gender might influence differently the psychomotor development of children with hemiplegia and of those with a more severe clinical involvement as diplegia and quadriplegia.