Objectives: we investigated the cause of hypo-responsiveness to vaccines in splenectomized subjects, Methods: we evaluated the immune responses to a Haemophilus influenzae type b vaccine and the sizes of lymphocyte subpopulations in 25 splenectomized and 45 non-splenectomized thalassaemic patients, in 12 individuals who had been splenectomized after trauma and in 20 controls. Results: the immune response in the controls was significantly higher (P < 0.001) than in splenectomized patients after trauma and in both, the response was higher (P < 0.001) than in thalassaemic patients. In asplenic subjects after trauma, percentages of CD3 and CD4 cells were lower (P < 0.001) than in patients in tile other groups: the controls had higher percentages of CDS cells (P < 0.001) than patients in the other groups, The natural logarithm of the mean percentage of CD19 showed a quadratic trend from thalassaemic patients through asplenic subjects to controls (P < 0.001). Levels of CD16(+) natural killer (NK) cells were higher (P < 0.001) only in asplenic subjects after trauma, Conclusions: the significant decrease in the immune response of the splenectomized thalassaemic patients vs. non-splenectomized thalassaemic patients may in part, be due to their basic immunological condition, Thus, the best strategy for protecting these subjects is to vaccinate them before the splenectomy
Immune responses to administration of a vaccine against Haemophilus influentiae type B in splenectomized and non-splenectomized patients
LI VOLTI, Giovanni;
1999-01-01
Abstract
Objectives: we investigated the cause of hypo-responsiveness to vaccines in splenectomized subjects, Methods: we evaluated the immune responses to a Haemophilus influenzae type b vaccine and the sizes of lymphocyte subpopulations in 25 splenectomized and 45 non-splenectomized thalassaemic patients, in 12 individuals who had been splenectomized after trauma and in 20 controls. Results: the immune response in the controls was significantly higher (P < 0.001) than in splenectomized patients after trauma and in both, the response was higher (P < 0.001) than in thalassaemic patients. In asplenic subjects after trauma, percentages of CD3 and CD4 cells were lower (P < 0.001) than in patients in tile other groups: the controls had higher percentages of CDS cells (P < 0.001) than patients in the other groups, The natural logarithm of the mean percentage of CD19 showed a quadratic trend from thalassaemic patients through asplenic subjects to controls (P < 0.001). Levels of CD16(+) natural killer (NK) cells were higher (P < 0.001) only in asplenic subjects after trauma, Conclusions: the significant decrease in the immune response of the splenectomized thalassaemic patients vs. non-splenectomized thalassaemic patients may in part, be due to their basic immunological condition, Thus, the best strategy for protecting these subjects is to vaccinate them before the splenectomyFile | Dimensione | Formato | |
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