Background: Treatment choice for chronic HBV infection is a continuously evolving issue, with a wide range ofoptions. We aimed to evaluate the current practice of HBV therapies in the real world in Southern Italy.Methods: A prospective study enrolling over a six month period (February–July 2010) all consecutive HBsAgpositive subjects, never previously treated, referred to 16 liver units in two Southern Italy regions (Calabriaand Sicily).Results: Out of 247 subjects evaluated, 116 (46.9%) had HBV-DNA undetectable or lower than 2000 UI/ml.There were 108 (43.7%) inactive carriers, 103 (41.7%) chronic hepatitis, and 36 (14.6%) liver cirrhosis. Antiviraltreatment was planned in 94 (38.0%) patients (26 cases with Interferon or Pegylated Interferon and68 with nucleos(t)ides analogues). As many as 49.5% of subjects with chronic hepatitis did not receiveantiviral treatment.Discussion: The majority of chronic HBsAg carrier referring centres for evaluation were not consideredsuitable for antiviral treatment. Nucleos(t)ides analogues are the preferred first choice for therapy. A longlastingperiod of observation may be needed to make appropriate therapeutic decisions in several cases.
|Titolo:||Current practice of chronic hepatitis B treatment in Southern Italy|
|Data di pubblicazione:||2012|
|Citazione:||Current practice of chronic hepatitis B treatment in Southern Italy / Stroffolini, T; Spadaro, A; Di Marco, V; Scifo, G; Russello, M; Montalto, G; Bertino, Gaetano; Surace, L; Caroleo, B; Foti, G; Portelli, V; Madonia, S; Sapienza, M; Cosco, L; Frugiuele, P; Galdieri, A; Brandolino, ; Siciliano, R; Bruno, S; Almasio, Pl; Hospitals' Collaborating Group, The G. r. E. C. a. S.. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 23:5(2012), pp. 124-127.|
|Appare nelle tipologie:||1.1 Articolo in rivista|