Multiple sclerosis (MS) is an immunoinflammatory disease of the central nervous system that seems to be influenced by DNA methylation. We sought to explore the expression pattern of genes involved in the control of DNA methylation in Secondary Progressive (SP) MS patients' PBMCs. We have found that SP MS is characterized by a significant upregulation of two genes belonging to the MBD family genes, MBD2 and MBD4, and by a downregulation of TDG and TET3.
Expression of DNA methylation genes in secondary progressive multiple sclerosis
FAGONE P;MANGANO, KATIA DOMENICA;DI MARCO R;SIGNORELLI, Salvatore;PATTI, Francesco;NICOLETTI, FERDINANDO
2016-01-01
Abstract
Multiple sclerosis (MS) is an immunoinflammatory disease of the central nervous system that seems to be influenced by DNA methylation. We sought to explore the expression pattern of genes involved in the control of DNA methylation in Secondary Progressive (SP) MS patients' PBMCs. We have found that SP MS is characterized by a significant upregulation of two genes belonging to the MBD family genes, MBD2 and MBD4, and by a downregulation of TDG and TET3.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Espression DNA methylation.pdf
solo gestori archivio
Tipologia:
Versione Editoriale (PDF)
Dimensione
680.53 kB
Formato
Adobe PDF
|
680.53 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
