Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses.

Botta, G; Bizzarri, Bm; Garozzo, Adriana; Timpanaro, R; Bisignano, B; Amatore, D; Palamara, At; Nencioni, L; Saladino, R.

doi:10.1016/j.bmc.2015.07.061

Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. All synthesized catechols were evaluated against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (Cox B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV). A significant antiviral activity was observed in the inhibition of HSV-1, HSV-2, Cox B3 and CMV. The mechanism of action of the most active dihydrocaffeoyl derivative was investigated against a model of HSV-1 infection.

Titolo:	Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses.
Autori interni:	Botta G Bizzarri BM GAROZZO, Adriana Timpanaro R Bisignano B Amatore D Palamara AT Nencioni L Saladino R. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Rivista:	BIOORGANIC & MEDICINAL CHEMISTRY
Handle:	http://hdl.handle.net/20.500.11769/47221
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/47221

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