Platelet to lymphocyte ratio, neutrophil to lymphocyte ratio and monocyte to HDL cholesterol ratio as markers of peripheral artery disease in elderly patients

Abstract. Solid evidence underlines the pivotal role played by inflammation regarding atherosclerosis. Peripheral artery disease (PAD) is one of atherosclerotic cardiovascular diseases(CVDs), it is highly frequently diagnosed in older indi viduals. In the present study we carried out an investigation on the association between platelet to lymphocytes ratio (PLR), neutrophil to lymphocyte ratio (NLR), monocyte to HDL cholesterol ratio (MHR) with PAD as favourable markers. We identified 300 subjects aged over 70 years, without any concomitant CVDs. The PLR, NLR and MHR were assessed from peripheral venous blood routinely drawn in the ward during hospitalization. Patients were divided in groups according to ankle brachial index (ABI) value (>0.9; 0.9 0.99; 1 1.4; >1.4). Higher PLR (P=0.007), NLR (P=0.0001) and MHR (P=0.0001) were associated with 1.4 ABI showed NLR values higher compared to >0.9l ABI (P