Background: Central and peripheral analgesia without adverse effects rely on the identification of μ opioid agonists able to activate “basal” antinociceptive pathways. Recently developed μ selective benzo-morphan agonists not antagonized by naloxone do not activate G-proteins and β-arrestins. Which path-ways μ receptor activates? How can each of them be selectively activated? What role is played by allosteric binding sites? Methodology & Results: Molecular Modeling studies characterize amino-acids residues involved in the interaction with different classes of endogenous/exogenous ligands, with agonists and an-tagonists. Conclusions: Critical binding differences between different classes of agonists with different pharmacological profiles have been identified. The binding poses of the MML series can be relevant for the search for an antinociception without side effects.

Pharmacological properties and biochemical mechanisms of MOR ligands might be due to different binding poses. MD Studies

Simone Ronsisvalle
Primo
;
Angelo Spadaro;Silvia Franchini;Matteo Pappalardo;Salvatore Guccione
Penultimo
;
Livia Basile
Ultimo
2020-01-01

Abstract

Background: Central and peripheral analgesia without adverse effects rely on the identification of μ opioid agonists able to activate “basal” antinociceptive pathways. Recently developed μ selective benzo-morphan agonists not antagonized by naloxone do not activate G-proteins and β-arrestins. Which path-ways μ receptor activates? How can each of them be selectively activated? What role is played by allosteric binding sites? Methodology & Results: Molecular Modeling studies characterize amino-acids residues involved in the interaction with different classes of endogenous/exogenous ligands, with agonists and an-tagonists. Conclusions: Critical binding differences between different classes of agonists with different pharmacological profiles have been identified. The binding poses of the MML series can be relevant for the search for an antinociception without side effects.
2020
opioid receptor, MOR, allosteric site, orthosteric site, molecular dynamics, molecular modeling, benzo-morphans
File in questo prodotto:
File Dimensione Formato  
Ronsisvalle et al. Future 2020.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Dimensione 1.85 MB
Formato Adobe PDF
1.85 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/481547
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact