Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; n=145) or walking exercise (n=151); 227 patients (exercise n=104; control n=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance6SD: baseline, 328696 m; 6 months, 3676113 m) but not in the control group (baseline, 3216107 m; 6 months, 3246116 m; P,0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time6SD: baseline, 20.566.0 seconds; 6 months, 18.265.7 seconds) but not in the control group (baseline, 20.965.8 seconds; 6 months, 20.266.4 seconds; P=0.001 between groups). The cognitive function score (P=0.04) and quality of social interaction score (P=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis.

Exercise in patients on dialysis: A multicenter, randomized clinical trial

Mallamaci F.;Fatuzzo P.
Membro del Collaboration Group
;
Rapisarda F.;Castellino P.;
2017-01-01

Abstract

Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; n=145) or walking exercise (n=151); 227 patients (exercise n=104; control n=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance6SD: baseline, 328696 m; 6 months, 3676113 m) but not in the control group (baseline, 3216107 m; 6 months, 3246116 m; P,0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time6SD: baseline, 20.566.0 seconds; 6 months, 18.265.7 seconds) but not in the control group (baseline, 20.965.8 seconds; 6 months, 20.266.4 seconds; P=0.001 between groups). The cognitive function score (P=0.04) and quality of social interaction score (P=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis.
2017
Exercise Therapy
Quality of Life
Walking
CKD
dialysis
exercise
physical functioning
rehabilitation
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/487229
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