Beta-catenin is a major protein in the Wntsignalling pathway. Although it has been studiedin various types of carcinoma, little isknown about its expression in mesenchymaltumours. In this study 41 specimens of a varietyof mesenchymal childhood tumours werecompared to 24 samples of the correspondingadult tumours to assess the diagnostic value ofnuclear β-catenin expression using tissuemicroarray-based immunohistochemistry.Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority ofchildhood sarcomas, and its nuclear translocationwas detected in paediatric fibromatosis;non-negligible levels of nuclear staining inother tumour types demonstrate Wnt pathwayactivation in mesenchymal neoplasms of childhoodand adolescence.
Role of beta-catenin expression in paediatric mesencymal lesions: a tissue microarray-based immunohistochemical study
LORETO, CARLA AGATA;
2012-01-01
Abstract
Beta-catenin is a major protein in the Wntsignalling pathway. Although it has been studiedin various types of carcinoma, little isknown about its expression in mesenchymaltumours. In this study 41 specimens of a varietyof mesenchymal childhood tumours werecompared to 24 samples of the correspondingadult tumours to assess the diagnostic value ofnuclear β-catenin expression using tissuemicroarray-based immunohistochemistry.Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority ofchildhood sarcomas, and its nuclear translocationwas detected in paediatric fibromatosis;non-negligible levels of nuclear staining inother tumour types demonstrate Wnt pathwayactivation in mesenchymal neoplasms of childhoodand adolescence.| File | Dimensione | Formato | |
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