Upper and lower airways diseases in childhood

In the last decade, extensive research has provided consistent advances in molecular biology and “omics” science (genomics, metabolomics, proteomics, and transcriptomics), which have led to the detailed characterization of the etiology, pathophysiological mechanisms, and subtypes of many diseases. Based on these developments, the concept of precision medicine was established. About a quarter of medical consultations related to primary care in children involves respiratory problems. About 10% of the cases are asthma, while the other most important respiratory diseases includes bronchiolitis, acute bronchitis and respiratory infections. Today, beyond the most common respiratory pathology, it is appropriate to discuss what are the novelties in the management of more complex, frequent and infrequent, pathologies because they are those in which it is possible to implement the concept of precision medicine.