Approximately half of glioblastoma (GBM) cases develop in geriatric patients, and this trend is destined to increase with the aging of the population. The optimal strategy for management of GBM in elderly patients remains controversial. The aim of this study was to assess the role of surgery in the elderly (≥ 65 years old) based on clinical, molecular, and imaging data routinely available in neurosurgical departments and to assess a prognostic survival score that could be helpful in stratifying the prognosis for elderly GBM patients.

Is age an additional factor in the treatment of elderly patients with glioblastoma? A new stratification model: an Italian Multicenter Study

Barbagallo, Giuseppe Maria;Certo, Francesco;
2020-01-01

Abstract

Approximately half of glioblastoma (GBM) cases develop in geriatric patients, and this trend is destined to increase with the aging of the population. The optimal strategy for management of GBM in elderly patients remains controversial. The aim of this study was to assess the role of surgery in the elderly (≥ 65 years old) based on clinical, molecular, and imaging data routinely available in neurosurgical departments and to assess a prognostic survival score that could be helpful in stratifying the prognosis for elderly GBM patients.
2020
CART = classification and regression tree
CART model
CCI = Charlson Comorbidity Index
EGBM = elderly GBM
EOR = extent of resection
GBM = glioblastoma
HR = hazard ratio
KPS = Karnofsky Performance Scale
OS = overall survival
PFS = progression-free survival
RHR = relative HR
classification and regression tree
decision tree diagram
elderly
extent of resection
glioblastoma surgery
prognostic score
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/497118
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