Objective: To investigate the effects of drospirenone on nasal respiratory epithelium in postmenopausal womenwho are treated with hormone therapy (HT).Design: Thirty-five naturally postmenopausal women participated in the prospective study. Women receivedcontinuous-combined HT containing 1 mg 17A-estradiol and 2 mg drospirenone. Cytological changes of nasalmiddle and inferior turbinate respiratory epithelium were evaluated by using the maturation index, performed atbaseline and on the sixth cycle of HT.Results: Hematoxylin-eosin staining for the maturation index of the epithelial nasal cells of women reachedbetter trophic aspects during 17A-estradiol/drospirenone intake with respect to those observed at baseline(P G 0.001). The smears during HT emphasized the superficial and the intermediate types of cells, with a ratioindex greater than 2. The parabasal cell content was less than 20%, and the karyopyknotic index showeddegenerative changes in superficial and intermediate cells.Conclusions: Our study confirmed that the nasal respiratory epithelium is an ovarian steroid target.Drospirenone acts on nasal cells similarly to other progestogens.

Characteristics of nasal epithelial cells in naturally postmenopausal women receiving hormone therapy with 1 mg of 17Beta-estradiol and 2 mg of drospirenone: a prospective study

CARUSO, Salvatore;SERRA, Agostino;GRILLO C;MAIOLINO, Luigi;CIANCI, Antonio
2008-01-01

Abstract

Objective: To investigate the effects of drospirenone on nasal respiratory epithelium in postmenopausal womenwho are treated with hormone therapy (HT).Design: Thirty-five naturally postmenopausal women participated in the prospective study. Women receivedcontinuous-combined HT containing 1 mg 17A-estradiol and 2 mg drospirenone. Cytological changes of nasalmiddle and inferior turbinate respiratory epithelium were evaluated by using the maturation index, performed atbaseline and on the sixth cycle of HT.Results: Hematoxylin-eosin staining for the maturation index of the epithelial nasal cells of women reachedbetter trophic aspects during 17A-estradiol/drospirenone intake with respect to those observed at baseline(P G 0.001). The smears during HT emphasized the superficial and the intermediate types of cells, with a ratioindex greater than 2. The parabasal cell content was less than 20%, and the karyopyknotic index showeddegenerative changes in superficial and intermediate cells.Conclusions: Our study confirmed that the nasal respiratory epithelium is an ovarian steroid target.Drospirenone acts on nasal cells similarly to other progestogens.
Drospirenone; Hormone therapy; Maturation index; Menopause; Nasal epithelium smear
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/50220
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