The protection role of melanin as an antioxidant biopolymer against lipid peroxidation was investigated. In pigmented frog liver and in albino rat liver the following were tested: thiobarbituric (TBA) reactive material (to show the induced lipoperoxidation in vitro), fatty acids, and reduced glutathione content. Our results show that susceptibility to the in vitro lipoperoxidation induced by ferrous ions is lower in the tissue containing melanin, though the content of the polynsaturated fatty acids is higher in pigmented than in unpigmented tissues and reduced glutathione levels are lower in pigmented tissue.Our data support the hypothesis that melanin could reduce lipoperoxidation in pigmented tissue
Lipid peroxidation in pigmented and unpigmented liver tissue: protective role of melanin.
SCALIA, Marina;
1990-01-01
Abstract
The protection role of melanin as an antioxidant biopolymer against lipid peroxidation was investigated. In pigmented frog liver and in albino rat liver the following were tested: thiobarbituric (TBA) reactive material (to show the induced lipoperoxidation in vitro), fatty acids, and reduced glutathione content. Our results show that susceptibility to the in vitro lipoperoxidation induced by ferrous ions is lower in the tissue containing melanin, though the content of the polynsaturated fatty acids is higher in pigmented than in unpigmented tissues and reduced glutathione levels are lower in pigmented tissue.Our data support the hypothesis that melanin could reduce lipoperoxidation in pigmented tissueI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
