Expression pattern of estroprogestinic receptors in sinonasal inverted papilloma

Inverted papilloma (IP) is a locally destructive, benign neoplasm of the noseand paranasal sinuses with a high tendency for recurrence, a significant potential formalignancy, and an etiology that today is still uncertain. The expression of hormonalreceptors in neoplastic tissues has been the focus of intensive research for its potentialdiagnostic, prognostic, and therapeutic significance. The aim of this study was toassess the potential estroprogestinic receptor expression in patients undergoing sinussurgery for IP. A retrospective study was carried out on surgical specimens of 73patients who underwent endoscopic sinus surgery for first manifestation of sinonasalIP (primitive IP group) and in 21 subjects who had developed a recurrence (relapsedIP group). The results of the immunohistochemical analysis of the first group showedthe absence of receptor expression for PGR in all cases analyzed and the presenceof a low positivity for ER in 11 cases (P > 0.082). Similarly, in the second group theresults showed a low presence of ER receptors in 3 of the 21 cases (P > 0.068), whilethere was no evidence of PGR receptors in the examined samples. In addition, in 11of the cases only 3 (27.2%) were considered positive showing a recurrence duringfollow-up (P > 0.068).