In this work we describe the chemical composition of Pteleopsis suberosa (Combretaceae) leaf extract and its biological activity against androgen-insensitive human prostate cancer cells (DU-145). The methanol extract of the plant leaves exhibited activity against tumor cell growth. Fractionation of this active extract led to the isolation and identification of sixteen flavonoids, including gallocatechin and flavonols having kaempferol, quercetin, and myricetin as aglycones. Among the myricetin derivatives, myricetin 3-O-(3″-acetyl)-α-L-arabinopyranoside (1) and myricetin 3-O-(4″-acetyl)-α-L-arabinopyranoside (2) are now reported for the first time. Six compounds, myricetin 3-O-α-L-rhamnopyranoside (4), myricetin 3-O-β-D-galactopyranoside (7), myricetin 3-O-(6″-galloyl)- β-D-galactopyranoside (9), myricetin 3-O-β-D-xylopyranoside (10), myricetin 3-O-α-L-arabinofuranoside (12), and gallocatechin (14), exhibited significant activity, reducing cell vitality and inducing apoptosis via the caspase-dependent pathway in DU-145 cells that can be, in part, correlated to modulation of redox-sensitive mechanisms.

Antiproliferative activity of Pteleopsis suberosa leaf extract and its flavonoid components in human prostate carcinoma cells

CARDILE, Venera;RUSSO, Alessandra
2006-01-01

Abstract

In this work we describe the chemical composition of Pteleopsis suberosa (Combretaceae) leaf extract and its biological activity against androgen-insensitive human prostate cancer cells (DU-145). The methanol extract of the plant leaves exhibited activity against tumor cell growth. Fractionation of this active extract led to the isolation and identification of sixteen flavonoids, including gallocatechin and flavonols having kaempferol, quercetin, and myricetin as aglycones. Among the myricetin derivatives, myricetin 3-O-(3″-acetyl)-α-L-arabinopyranoside (1) and myricetin 3-O-(4″-acetyl)-α-L-arabinopyranoside (2) are now reported for the first time. Six compounds, myricetin 3-O-α-L-rhamnopyranoside (4), myricetin 3-O-β-D-galactopyranoside (7), myricetin 3-O-(6″-galloyl)- β-D-galactopyranoside (9), myricetin 3-O-β-D-xylopyranoside (10), myricetin 3-O-α-L-arabinofuranoside (12), and gallocatechin (14), exhibited significant activity, reducing cell vitality and inducing apoptosis via the caspase-dependent pathway in DU-145 cells that can be, in part, correlated to modulation of redox-sensitive mechanisms.
2006
Antiproliferative activity, Combretaceae, Flavonoids, Pteleopsis suberosa
File in questo prodotto:
File Dimensione Formato  
10.1055s-2006-931556.pdf

solo gestori archivio

Dimensione 580.31 kB
Formato Adobe PDF
580.31 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/5132
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 29
social impact