In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ET Ah and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6-trimethylphenyl) benzamide (23) was the most interesting
Synthesis and Binding Properties of New Endothelin Receptor Ligands / Modica, Maria Nunziata; Salerno, Loredana; Pittala', Valeria; Romeo, Giuseppe; Siracusa, Maria Angela; Mereghetti, I; Cagnotto, A; Mennini, T.. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 4(2007), pp. 232-238.
Titolo: | Synthesis and Binding Properties of New Endothelin Receptor Ligands |
Autori interni: | |
Data di pubblicazione: | 2007 |
Rivista: | |
Citazione: | Synthesis and Binding Properties of New Endothelin Receptor Ligands / Modica, Maria Nunziata; Salerno, Loredana; Pittala', Valeria; Romeo, Giuseppe; Siracusa, Maria Angela; Mereghetti, I; Cagnotto, A; Mennini, T.. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 4(2007), pp. 232-238. |
Handle: | http://hdl.handle.net/20.500.11769/5143 |
Appare nelle tipologie: | 1.1 Articolo in rivista |