We report here a fatal case of nosocomial pneumonia due to a multidrug-resistant (MDR) strain of Enterobactercloacae, which was also resistant to carbapenems, in a patient with a diagnosis of Churg-Strauss syndrome. Themicroorganism was investigated for the presence of metallo- and extended-spectrum b-lactamases. The strainproduced two class 1 integrons carrying blaVIM-1 and aadA2 gene cassettes located on chromosomal and plasmidicDNA, respectively, and a plasmid-encoded SHV-12 extended-spectrum b-lactamase. Our results clearlydemonstrate the transfer of this kind of resistance in E. cloacae with potentially serious clinical implications
Class I integron-borne blaVIM-1 carbapenemase in a strain of Enterobacter cloacae responsible for a case of fatal pneumonia
MEZZATESTA M;STEFANIA STEFANI
2008-01-01
Abstract
We report here a fatal case of nosocomial pneumonia due to a multidrug-resistant (MDR) strain of Enterobactercloacae, which was also resistant to carbapenems, in a patient with a diagnosis of Churg-Strauss syndrome. Themicroorganism was investigated for the presence of metallo- and extended-spectrum b-lactamases. The strainproduced two class 1 integrons carrying blaVIM-1 and aadA2 gene cassettes located on chromosomal and plasmidicDNA, respectively, and a plasmid-encoded SHV-12 extended-spectrum b-lactamase. Our results clearlydemonstrate the transfer of this kind of resistance in E. cloacae with potentially serious clinical implications| File | Dimensione | Formato | |
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