The incorporation of lipophilic phosphonodithioesters in phospholipid formulations generates clickable liposomes that react with amines. The kinetics of this metal free phosphonodithioester-amine coupling (PAC) on liposomes in water is reported and can be classified as a fast reaction with a second order rate constant ofk≈ 8 × 102M−1s−1. The PAC reaction represents a versatile strategy to functionalize liposomes.
Phosphonodithioester-amine coupling in water: a fast reaction to modify the surface of liposomes
Fraix A.;Sortino S.;
2021-01-01
Abstract
The incorporation of lipophilic phosphonodithioesters in phospholipid formulations generates clickable liposomes that react with amines. The kinetics of this metal free phosphonodithioester-amine coupling (PAC) on liposomes in water is reported and can be classified as a fast reaction with a second order rate constant ofk≈ 8 × 102M−1s−1. The PAC reaction represents a versatile strategy to functionalize liposomes.File in questo prodotto:
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