"Spasmodic dysphonia in multiple sclerosis treatment with botulinum toxin: a pilot study."

OBJECTIVES:This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation.MATERIALS AND METHODS:This is a pilot study on three relapsing-remitting MS patients with SD and their response to botulin toxin A.RESULTS:None of the patients reported dysphagia or other adverse events. Significant improvement was observed in terms of both voice quality and laryngostroboscopy results. The treatment effect was durable for 6-8 months.CONCLUSIONS:Botulin toxin A is a safe treatment that can be successfully used to treat SD in patients with MS. Larger studies are necessary to confirm our results.