L-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.

Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme

A. Distefano
Primo
;
G. Caruso;V. Oliveri;F. Bellia;G. A. Zingale;F. Caraci
Penultimo
;
G. Grasso
Ultimo
2022-01-01

Abstract

L-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.
2022
diabetes, Alzheimer’s disease, insulin, IDE, carnosine, neuropeptides
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/528837
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