Objective: To compare the pregnancy outcome in patients undergoing in vitro fertilization-embryo transfer (IVF-ET) cycles, using human derived foilicle-stimulating hormone (FSH) or recombinant FSH for ovarian stimulation protocols. Design: Prospective, multi-centre, randomized controlled trial. Patients: 115 infertile patients undergoing a first attempt of in vitro fertilization and embryo transfer were included in the study. The inclusion criteria were: female age <37 years and use of GnRH agonist (GnRH-a) for pituitary down-regulation. Interventions: Long Protocol-controlled ovarian stimulation with human derived FSH or recombinant FSH for IVF-ET. Main Outcome Measures: Primary end-points were implantation rate, clinical pregnancy rate and spontaneous abortion rate. Secondary end-points were total units of FSH injected, days of stimulation, peak estradiol levels at point of hCG administration, mean number of oocytes at pick-up, fertilization rate and cleavage rate. Results: No statistically significantly differences in pregnancy outcomes were found in the patients receiving hFSH in comparison to patients receiving rFSH. Conclusions: This study did not demonstrate a difference between the use of h-FSH vs r-FSH for ovarian stimulation in terms of pregnancy outcome, in good prognosis patients undergoing their first IVF-ET procedure.
OBJECTIVE: To compare the pregnancy outcome in patients undergoing in vitro fertilization-embryo transfer (IVF-ET) cycles, using human derived follicle-stimulating hormone (FSH) or recombinant FSH for ovarian stimulation protocols. DESIGN: Prospective, multi-centre, randomized controlled trial. PATIENTS: 115 infertile patients undergoing a first attempt of in vitro fertilization and embryo transfer were included in the study. The inclusion criteria were: female age < 37 years and use of GnRH agonist (GnRH-a) for pituitary downregulation. INTERVENTIONS: Long Protocol-controlled ovarian stimulation with human derived FSH or recombinant FSH for IVF-ET. MAIN OUTCOME MEASURES: Primary endpoints were implantation rate, clinical pregnancy rate and spontaneous abortion rate. Secondary end-points were total units of FSH injected, days of stimulation, peak estradiol levels at point of hCG administration, mean number of oocytes at pick-up, fertilization rate and cleavage rate. RESULTS: No statistically significantly differences in pregnancy outcomes were found in the patients receiving hFSH in comparison to patients receiving rFSH. CONCLUSIONS: This study did not demonstrate a difference between the use of h-FSH vs r-FSH for ovarian stimulation in terms of pregnancy outcome, in good prognosis patients undergoing their first IVF-ET procedure.
Pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET) in women aged < 37, undergoing ovulation induction with human FSH compared with recombinant FSH: a randomised controlled study
VICARI, Enzo Saretto;LA VIGNERA, SANDRO SALVUCCIO MARIA;
2010-01-01
Abstract
Objective: To compare the pregnancy outcome in patients undergoing in vitro fertilization-embryo transfer (IVF-ET) cycles, using human derived foilicle-stimulating hormone (FSH) or recombinant FSH for ovarian stimulation protocols. Design: Prospective, multi-centre, randomized controlled trial. Patients: 115 infertile patients undergoing a first attempt of in vitro fertilization and embryo transfer were included in the study. The inclusion criteria were: female age <37 years and use of GnRH agonist (GnRH-a) for pituitary down-regulation. Interventions: Long Protocol-controlled ovarian stimulation with human derived FSH or recombinant FSH for IVF-ET. Main Outcome Measures: Primary end-points were implantation rate, clinical pregnancy rate and spontaneous abortion rate. Secondary end-points were total units of FSH injected, days of stimulation, peak estradiol levels at point of hCG administration, mean number of oocytes at pick-up, fertilization rate and cleavage rate. Results: No statistically significantly differences in pregnancy outcomes were found in the patients receiving hFSH in comparison to patients receiving rFSH. Conclusions: This study did not demonstrate a difference between the use of h-FSH vs r-FSH for ovarian stimulation in terms of pregnancy outcome, in good prognosis patients undergoing their first IVF-ET procedure.File | Dimensione | Formato | |
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