Skin wounds are exposed to a series of events that culminate in healing. This process is well known in relation to histological events, although mechanisms that underlie its regulation remain unclear, since not only are tissue growth factors involved, but also a number of cytokines. The present study focuses on treatment of chronic ulcers of lower limbs of two patients with recombinant human GM-CSF (rHuGM-CSF); the results were encouraging. Colony granulocyte/macrophage stimulating factor (GM-CSF) could be included between compounds promoting healing, in relation to direct or indirect effects of topical GM-CSF administration. Further study will be needed to determine dosage, method of application, and the type of recombinant material that will achieve the best results.

Wound healing: experience with rHuGM-CSF

CASTROGIOVANNI, Paola
Primo
;
IMBESI, Rosa
Ultimo
2010

Abstract

Skin wounds are exposed to a series of events that culminate in healing. This process is well known in relation to histological events, although mechanisms that underlie its regulation remain unclear, since not only are tissue growth factors involved, but also a number of cytokines. The present study focuses on treatment of chronic ulcers of lower limbs of two patients with recombinant human GM-CSF (rHuGM-CSF); the results were encouraging. Colony granulocyte/macrophage stimulating factor (GM-CSF) could be included between compounds promoting healing, in relation to direct or indirect effects of topical GM-CSF administration. Further study will be needed to determine dosage, method of application, and the type of recombinant material that will achieve the best results.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/5404
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
social impact