The epithelium, once simply considered a protective barrier against harmful agents, has in recent times gained considerable relevance as an entity that can pro- mote and regulate inflammatory processes through the production of cytokines, namely interleukin (IL) -25, IL -33 and thymic stromal lymphopoietin (TSLP), known as "alarmins". TSLP, in particular, has been extensively studied as a possible therapeutic target in patients with severe asthma because it is involved in the infla- mmatory processes of both type 2 -high and type 2 -low inflammation. In this regard, tezepelumab (AMG-157/ MEDI-9929), a TSLP-targeted first-in -class fully human monoclonal antibody, has been shown in phase II and III studies to be effective and safe in treating patients with severe asthma, regardless of the underlying endo- type or phenotype and irrespective of baseline bio- markers, such as blood eosinophil count and fraction of exhaled nitric oxide. Here, we provide a comprehen- sive review of TSLP function in airway inflammatory processes, the clinical development of tezepelumab for severe asthma as well as its possible future indications.
Tezepelumab for asthma
Nolasco, SantiPrimo
Writing – Original Draft Preparation
;Campisi, RaffaelePenultimo
Writing – Review & Editing
;Crimi, Claudia
Ultimo
Writing – Review & Editing
2022-01-01
Abstract
The epithelium, once simply considered a protective barrier against harmful agents, has in recent times gained considerable relevance as an entity that can pro- mote and regulate inflammatory processes through the production of cytokines, namely interleukin (IL) -25, IL -33 and thymic stromal lymphopoietin (TSLP), known as "alarmins". TSLP, in particular, has been extensively studied as a possible therapeutic target in patients with severe asthma because it is involved in the infla- mmatory processes of both type 2 -high and type 2 -low inflammation. In this regard, tezepelumab (AMG-157/ MEDI-9929), a TSLP-targeted first-in -class fully human monoclonal antibody, has been shown in phase II and III studies to be effective and safe in treating patients with severe asthma, regardless of the underlying endo- type or phenotype and irrespective of baseline bio- markers, such as blood eosinophil count and fraction of exhaled nitric oxide. Here, we provide a comprehen- sive review of TSLP function in airway inflammatory processes, the clinical development of tezepelumab for severe asthma as well as its possible future indications.File | Dimensione | Formato | |
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