In genuary 1991 a Protocol for Germ cell Tumors in children was actuated; 167 patients (pts.) were enrolled. Treatment was based on histology, site, staging. Mature Teratoma (T.): 73 pts.: 2 relapses, with malignant transformation in I case; all the pts. are alive without evident disease, after 3-65 mo. from diagnosis. Immature T.: 25 pts.: 5 relapses, with malignant trasformation in I case; all the pts. are alive, with residual mass in I case, lasting 3-59 mo. MNSGCT: 46 pts.: 1 pt. was no responder, 7 pts. had relapse: three of them with testicular tumor, are in II remission; 4 pts. died for progressive disease; four died for complications (one after relapse). Overall survival: 82,6%, with a median observation time of 30 mo. Fatal outcome occurred in 4/17 (23%) sacrococcigeal tumor and in the mediastinal tumor. Seminoma: 10 pts.: 2 relapses; all the pts. are alive after 15-65 mo. from diagnosis. Conclusion: long term surveillance is indicated in Mature T. The need for chemotherapy in Immature T. is no clear. Malignamt tumors are at high risk mainly for the s.c. localisation. Our data suggest tha reduction of chemotherapy in malignant localised tumors.
Germ cell tumors in childhood | [Tumori a cellule germinali in età pediatrica]
DI CATALDO, Andrea;
1997-01-01
Abstract
In genuary 1991 a Protocol for Germ cell Tumors in children was actuated; 167 patients (pts.) were enrolled. Treatment was based on histology, site, staging. Mature Teratoma (T.): 73 pts.: 2 relapses, with malignant transformation in I case; all the pts. are alive without evident disease, after 3-65 mo. from diagnosis. Immature T.: 25 pts.: 5 relapses, with malignant trasformation in I case; all the pts. are alive, with residual mass in I case, lasting 3-59 mo. MNSGCT: 46 pts.: 1 pt. was no responder, 7 pts. had relapse: three of them with testicular tumor, are in II remission; 4 pts. died for progressive disease; four died for complications (one after relapse). Overall survival: 82,6%, with a median observation time of 30 mo. Fatal outcome occurred in 4/17 (23%) sacrococcigeal tumor and in the mediastinal tumor. Seminoma: 10 pts.: 2 relapses; all the pts. are alive after 15-65 mo. from diagnosis. Conclusion: long term surveillance is indicated in Mature T. The need for chemotherapy in Immature T. is no clear. Malignamt tumors are at high risk mainly for the s.c. localisation. Our data suggest tha reduction of chemotherapy in malignant localised tumors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
