Single-nucleotide polymorphism and downstream signaling associated with chronic rhinosinusitis, asthma, allergy and acetylsalicylic-acid intolerance: a narrative review

Objectives: Different Single nucleotide polymorphisms have been described in the literature as being significantly associated with a greater risk than the general population of developing impaired downstream signalling and comorbidities such as chronic rhinosinusitis, asthma, allergy and ASA intolerance. We conducted a narrative review on comorbidities related to chronic rhinosinusitis such as asthma, allergies, and ASA intolerance among the English-language literature from the past 20 years regarding chronic rhinosinusitis and the association with asthma, allergies, and ASA intolerance was performed. Results: We retrieved 12 papers with 9127 patients, of which 2739 CRS cases vs. 6388 controls. The major comorbidities associated with chronic rhinosinusitis were allergy (n = 4555; 49.9%), asthma in (n = 4594; 50.33%), Samter Triad (n = 448; 4.9%) and eosinophilia in subjects (n = 391; 4.28%). Conclusions: Our narrative review investigated the major comorbidities significantly associated with chronic rhinosinusitis. Although there is clinical evidence, given the presence of different inclusion methods and given the variability of the populations examined, further studies with larger cohorts are needed to identify stronger associations with the comorbidities and single nucleotide polymorphisms