Do Vγ2Vδ2 T cells influence HIV disease progression?

gd T cells are believed to play a criticalrole in linking innate and acquired immunity.They produce INF-g, a cytokineof the T helper 1 pathway that has a protectiveactivity in HIV disease progression[1]. gd T cells are generally CD4 andCD8 negative, produce large amounts ofcytokines on activation, and recognizephosphorilated nonpeptidic antigens in amajor histocompatibility complex–unrestrictedmanner. As such, they do not requireantigen-presenting cell processingand presentation [1]. Furthermore, thesecells are reactive against Mycobacteriumtuberculosis, intracellular pathogens, andHIV. In vitro, Vg2Vd2 T cells have beenshown to posses diverse anti-HIV activities