The acquired immunodeficiency syndrome (AIDS) is accompanied by a significant increase in theincidence of neoplasms. Several causative agents have been proposed for this phenomenon. Theseinclude immunodeficiency and oncogenic DNA viruses and the HIV-1 protein Tat. Cancer ingeneral is closely linked to genomic instability and DNA repair mechanisms. The latter maintainsgenomic stability and serves as a cellular anti-cancer barrier. Defects in DNA repair pathway areassociated with carcinogenesis.This review focuses on newly discovered connections of the HIV-1 protein Tat, as well as cellularco-factors of Tat, to double-strand break DNA repair. We propose that the Tat-induced DNArepair deficiencies may play a significant role in the development of AIDS-associated cancer.
HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
NUNNARI GPrimo
;
2008-01-01
Abstract
The acquired immunodeficiency syndrome (AIDS) is accompanied by a significant increase in theincidence of neoplasms. Several causative agents have been proposed for this phenomenon. Theseinclude immunodeficiency and oncogenic DNA viruses and the HIV-1 protein Tat. Cancer ingeneral is closely linked to genomic instability and DNA repair mechanisms. The latter maintainsgenomic stability and serves as a cellular anti-cancer barrier. Defects in DNA repair pathway areassociated with carcinogenesis.This review focuses on newly discovered connections of the HIV-1 protein Tat, as well as cellularco-factors of Tat, to double-strand break DNA repair. We propose that the Tat-induced DNArepair deficiencies may play a significant role in the development of AIDS-associated cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
