Hepatitis C virus infection is the main cause ofliver disease worldwide, often leading to chronichepatitis. Recent studies have demonstrated thatmiRNA-122, a liver-specific miRNA, is required forHCV replication in hepatocytes by its binding to the 5’UTR of HCV. Down-regulation of miRNA-122 in vitroand in vivo has led to significant inhibition of viralreplication. In the present article, we report the majorrecent findings on the p
MicroRNA-122: a therapeutic target for hepatitis C virus (HCV) infection
Nunnari G
2011-01-01
Abstract
Hepatitis C virus infection is the main cause ofliver disease worldwide, often leading to chronichepatitis. Recent studies have demonstrated thatmiRNA-122, a liver-specific miRNA, is required forHCV replication in hepatocytes by its binding to the 5’UTR of HCV. Down-regulation of miRNA-122 in vitroand in vivo has led to significant inhibition of viralreplication. In the present article, we report the majorrecent findings on the pFile in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
