The aim of this experimental study is to evaluate, in vitro, the chemical composition and the micromorphological structure of a bone substitute material surface. This material is based on calcium triphosphate and hydroxyapatite microgranules. Some results of a preliminary surface study of the above mentioned bioceramic materials are reported. The study has been carried out by means of time-of-flight secondary ion mass spectrometry (TOF-SIMS), complemented by X-ray photoelectron spectrometry (XPS) measurements. Whereas XPS data supplies the average surface composition of the system, TOF-SIMS supplies laterally and depth resolved information on the sample. This preliminary study confirms the properties of osteoconduction and scaffold features of the material. Moreover, a possible osteoinductive capability could be due to the presence of surface micropores, which could help in the attraction of bone morphogenetic protein (BMP), thus promoting the osteogenesis. © 2016 Springer Science+Business Media New York.
TOF-SIMS application for evaluating the atomic structure of new bone substitute material
CICCIU', Marco
2016-01-01
Abstract
The aim of this experimental study is to evaluate, in vitro, the chemical composition and the micromorphological structure of a bone substitute material surface. This material is based on calcium triphosphate and hydroxyapatite microgranules. Some results of a preliminary surface study of the above mentioned bioceramic materials are reported. The study has been carried out by means of time-of-flight secondary ion mass spectrometry (TOF-SIMS), complemented by X-ray photoelectron spectrometry (XPS) measurements. Whereas XPS data supplies the average surface composition of the system, TOF-SIMS supplies laterally and depth resolved information on the sample. This preliminary study confirms the properties of osteoconduction and scaffold features of the material. Moreover, a possible osteoinductive capability could be due to the presence of surface micropores, which could help in the attraction of bone morphogenetic protein (BMP), thus promoting the osteogenesis. © 2016 Springer Science+Business Media New York.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
