The concomitant presence of Castleman disease with other hematological pathology is an event described in the literature with increasing frequency, able to modify the diagnostic and curative approach in such patients. Very few studies in the literature describe the association of CD with concomitant neoplastic diseases: the most frequent are Kaposi's sarcomas (especially in HIV and HHV-8 positive patients) and lymphoproliferative disorders, such as lymphomas. Instead, since the association with plasma cell diseases such as multiple myeloma and plasmacytoma is infrequent, there is lacking literature. This manuscript aims to revise the literature by describing a rare case of CD and plasmacytoma and attempting to explain the underlying triggering mechanisms.

Multicentric Castleman disease and concurrent hematological disorders: the occurrence of plasmacytoma and the hypotheses arising from literature's review

Duminuco, Andrea
Primo
;
Romano, Alessandra;Elia, Federica;Palumbo, Giuseppe A;Di Raimondo, Francesco;Conticello, Concetta
Ultimo
2023-01-01

Abstract

The concomitant presence of Castleman disease with other hematological pathology is an event described in the literature with increasing frequency, able to modify the diagnostic and curative approach in such patients. Very few studies in the literature describe the association of CD with concomitant neoplastic diseases: the most frequent are Kaposi's sarcomas (especially in HIV and HHV-8 positive patients) and lymphoproliferative disorders, such as lymphomas. Instead, since the association with plasma cell diseases such as multiple myeloma and plasmacytoma is infrequent, there is lacking literature. This manuscript aims to revise the literature by describing a rare case of CD and plasmacytoma and attempting to explain the underlying triggering mechanisms.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/558187
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