Gut-Targeted Immunonutrition Boosting Natural Killer Cell Activity Using Saccharomyces boulardii Lysates in Immuno-Compromised Healthy Elderly Subjects

The aim of this study was to assess the immunomodulatory effect of KC-1317 (a symbiotic mixture containing Saccharomyces boulardii lysate in a cranberry, colostrum-derived lactoferrin, fragaria and lactose mixture) supplementation in immune compromised but otherwise healthy elderly subjects. A liquid form formulation of KC-1317 was administered in a RCT fashion to healthy volunteers (65-79 years) previously selected for low NK cell activity and this parameter was checked at the completion of the study. A significant improvement in NK cell activity of KC-1317 consumers was observed as compared to placebo at the end of 2 months. These albeit preliminary beneficial immune-modulatory effect of KC-1317 in aged individuals might envisage its employs within a wider age-management strategy.