Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases

Panerai, A. E.; Sacerdote, P.; Bianchi, M.; Nicoletti, Ferdinando; Manfredi, B.; Gaspani, L.; Bartorelli, A.; Ceciliani, F.; Ronchi, S.

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UK-114 is a 14-kDa ubiquitous protein recently sequenced by several groups throughout the world. Its activity ranges from being a tumor antigen, a protein synthesis inhibitor or a specific μ-calpain activator, UK-114 shows structural homologies also with proteins of the MHC-1 binding proteins, and heat shock proteins (HSPs). We investigated the possible effects of UK-114 on T helper cells cytokine profile and the development and progression of experimental autoimmune diseases. Homogeneous recombinant UK-114 was used in all experiments. Treatment of Balb/c male mice for two weeks resulted in the increase of IL-4, and the decrease of TNF-α, IFN-γ, and IL-2 release from stimulated splenocytes, suggesting that UK-114 modulates the Th1/Th2 cytokine profile toward Th2. Similar to that observed with HSP60/65, a single pretreatment of Lewis rats with UK-114 significantly blunted the development of adjuvant-induced arthritis, whereas chronic treatment of 4-week-old female NOD mice dose dependently inhibited the development of diabetes.

Titolo:	Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases
Autori interni:	Panerai, A. E. Sacerdote, P. Bianchi, M. NICOLETTI, FERDINANDO Manfredi, B. Gaspani, L. Bartorelli, A. Ceciliani, F. Ronchi, S. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1999
Rivista:	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Handle:	http://hdl.handle.net/20.500.11769/58221
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/58221

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