Stroke is a devastating condition with significant morbidity and mortality worldwide. Antithrombotic therapy plays a crucial role in both primary and secondary prevention of stroke events. Single or dual antiplatelet therapy is generally preferred in cases of large-artery atherosclerosis and small-vessel disease, whereas anticoagulation is recommended in conditions of blood stasis or hypercoagulable states that mostly result in red thrombi. However, the benefit of antithrombotic therapies must be weighed against the increased risk of bleeding, which can pose significant challenges in the pharmacological management of this condition. This review provides a comprehensive summary of the currently available evidence on antithrombotic therapy for ischemic stroke and outlines an updated therapeutic algorithm to support physicians in tailoring the strategy to the individual patient and the underlying mechanism of stroke. (c) 2023 by the American College of Cardiology Foundation.

Antithrombotic Therapy for Primary and Secondary Prevention of Ischemic Stroke

Greco, Antonio;Occhipinti, Giovanni;Giacoppo, Daniele;Agnello, Federica;Laudani, Claudio;Spagnolo, Marco;Mauro, Maria Sara;Rochira, Carla;Finocchiaro, Simone;Mazzone, Placido Maria;Faro, Denise Cristiana;Landolina, Davide;Ammirabile, Nicola;Imbesi, Antonino;Raffo, Carmelo;Capodanno, Davide
2023-01-01

Abstract

Stroke is a devastating condition with significant morbidity and mortality worldwide. Antithrombotic therapy plays a crucial role in both primary and secondary prevention of stroke events. Single or dual antiplatelet therapy is generally preferred in cases of large-artery atherosclerosis and small-vessel disease, whereas anticoagulation is recommended in conditions of blood stasis or hypercoagulable states that mostly result in red thrombi. However, the benefit of antithrombotic therapies must be weighed against the increased risk of bleeding, which can pose significant challenges in the pharmacological management of this condition. This review provides a comprehensive summary of the currently available evidence on antithrombotic therapy for ischemic stroke and outlines an updated therapeutic algorithm to support physicians in tailoring the strategy to the individual patient and the underlying mechanism of stroke. (c) 2023 by the American College of Cardiology Foundation.
2023
anticoagulation
antiplatelet therapy
antithrombotic therapy
prevention
stroke
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/590132
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