VALIDITA’ CLINICA ED IMMUNOLOGICA DI UNA PASTA DENTIFRICIA CONTENENTI ANTIGENI BATTERICI

Oral vaccines made up of immobilised microc agents have demonstrated optimum antigenic characteristics. The authors introduce the results of their research on the antigenic efficiency of a toothpaste (the Dentovax, includig Escherichia coli, Streptocuccus oralis, Staphylococcus auresus, Proteus vulgaris) aginst perodontopathologies, supporting clinical expriences with the results of in vitro tests. Forty male and female patients aged between 18 and 40 and sffering from marginal or deep gingivites, were randomly subdivided into groups of 20. The one gruop was treated with Dentovax twice daily for 15 days (Grupo A) and the other with conventional toothpaste for the same number of germs (Group B). The dental plaque was then removed from the gingival groove, checking the presence af acrobical and anaerobical bacteria in oder to evaluate the possible variations before and after the 15-day treatment with Dentovax. A semple of saliva was taken before and after the treatment for the assay of AgA secretin. The bacteriological results obtanies demostrate a remarkable improvement of flora in the patients treated with Dentovax with respect tothe group treated with conventional toothpaste. This fact was confirmed by the better clinica results observed in Group A patients with respect to Group B patients. These good results are determineted above all by the increase in IgA secretion aginst the possible and eventual phlogistic effect of the product.