The consumption of soft drinks is a crucial factor in determining persistent hypocalcemia.The aim of the study is to evaluate the biochemical mechanisms inducing hypocalcemiain a female patient with usual high consumption of cola drink and persistent hypocalcemia,who failed to respond to high doses of calcium and calcitriol supplementation. Atbaseline and after pentagastrin injection, gastric secretion (Gs) and duodenal secretion(Ds) samples were collected and calcium and total phosphorus (Ptot) concentrationswere evaluated. At the same time, blood calcium, Ptot, sodium, potassium, chloride,magnesium concentrations, and vitamin D were sampled. After intake of cola (1 L) over180 min, Gs and Ds and blood were collected and characterized in order to analyzethe amount of calcium and Ptot or sodium, potassium, magnesium, and chloride ions,respectively. A strong pH decrease was observed after cola intake with an increase inphosphorus concentration. Consequently, a decrease in calcium concentration in Gsand Ds was observed. A decrease in calcium concentration was also observed in blood.In conclusion, we confirm that in patients with postsurgical hypoparathyroidism, theintake of large amounts of cola containing high amounts of phosphoric acid reducescalcium absorption efficiency despite the high doses of calcium therapy.
The Daily Consumption of Cola Can Determine Hypocalcemia: A Case Report of Postsurgical Hypoparathyroidism-Related Hypocalcemia Refractory to Supplemental Therapy with High Doses of Oral Calcium
RIELA, Serena;
2017-01-01
Abstract
The consumption of soft drinks is a crucial factor in determining persistent hypocalcemia.The aim of the study is to evaluate the biochemical mechanisms inducing hypocalcemiain a female patient with usual high consumption of cola drink and persistent hypocalcemia,who failed to respond to high doses of calcium and calcitriol supplementation. Atbaseline and after pentagastrin injection, gastric secretion (Gs) and duodenal secretion(Ds) samples were collected and calcium and total phosphorus (Ptot) concentrationswere evaluated. At the same time, blood calcium, Ptot, sodium, potassium, chloride,magnesium concentrations, and vitamin D were sampled. After intake of cola (1 L) over180 min, Gs and Ds and blood were collected and characterized in order to analyzethe amount of calcium and Ptot or sodium, potassium, magnesium, and chloride ions,respectively. A strong pH decrease was observed after cola intake with an increase inphosphorus concentration. Consequently, a decrease in calcium concentration in Gsand Ds was observed. A decrease in calcium concentration was also observed in blood.In conclusion, we confirm that in patients with postsurgical hypoparathyroidism, theintake of large amounts of cola containing high amounts of phosphoric acid reducescalcium absorption efficiency despite the high doses of calcium therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
