A number of new pyrimido[5,4-b]indole and [1]benzothieno[3,2-d]pyrimidine derivatives were synthesized and evaluatedfor their binding and functional properties at alpha1-adrenergic receptor (alpha1-AR) subtypes. They behaved as potent alpha1-AR antagonists.In binding experiments, some of them (RC24 and RC23) showed very high affinity for the alpha1D-AR subtype.
New Pyrimido[5,4-b]indoles and [1]Benzothieno[3,2-d]pyrimidines. High Affinity Ligands for the a 1 - Adrenoceptor Subtypes
ROMEO, Giuseppe;MODICA, Maria Nunziata;PITTALA', Valeria;SALERNO, Loredana;SIRACUSA, Maria Angela;
2006-01-01
Abstract
A number of new pyrimido[5,4-b]indole and [1]benzothieno[3,2-d]pyrimidine derivatives were synthesized and evaluatedfor their binding and functional properties at alpha1-adrenergic receptor (alpha1-AR) subtypes. They behaved as potent alpha1-AR antagonists.In binding experiments, some of them (RC24 and RC23) showed very high affinity for the alpha1D-AR subtype.File in questo prodotto:
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