The synthesis and spectroscopic characterization of trans 1-(indol-2-yl)-2-(1-methylpyridinium and 1-methylquinolinium-2-yl) ethylenes is reported. In vitro antitumour activity tests show that quinolinium derivatives are more active towards MCF7 (breast), LNCap (prostate) and U87 (human gliobastoma) carcinoma cells than pyridinium ones.
Synthesis and applications of new trans 1-indolyl-2-(1-methylpyridinium and quinolinium-2-yl)ethylenes
FORTUNA, COSIMO GIANLUCA;BARRESI, VINCENZA;MUSUMARRA, Giuseppe
2009-01-01
Abstract
The synthesis and spectroscopic characterization of trans 1-(indol-2-yl)-2-(1-methylpyridinium and 1-methylquinolinium-2-yl) ethylenes is reported. In vitro antitumour activity tests show that quinolinium derivatives are more active towards MCF7 (breast), LNCap (prostate) and U87 (human gliobastoma) carcinoma cells than pyridinium ones.File in questo prodotto:
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