Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennialclimbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic andantilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may represent an importantpathogenic mechanism in obesity-associated metabolic syndrome. The present studyevaluated free radical scavenging capacity of different concentrations of aqueous,methanolic and dichloromethane leaf extracts of Momordica foetida Schumach. et Thonn.and the ability of these extracts to inhibit in vitro plasma lipid peroxidation; in addition,healthy human adipose mesenchymal stem cell cultures were used in order to test the hypothesis that these extracts may affect adipocyte differentiation. Results obtained in thisstudy suggested that aqueous extract might be useful in preventing metabolic syndrome.

Antioxidant activity of extracts of Momordica foetida Schumach. et Thonn.

ACQUAVIVA, ROSARIA;DI GIACOMO, Claudia;VANELLA, LUCA;SORRENTI, Valeria;BARBAGALLO, IGNAZIO ALBERTO;Genovese C;
2013-01-01

Abstract

Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennialclimbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic andantilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may represent an importantpathogenic mechanism in obesity-associated metabolic syndrome. The present studyevaluated free radical scavenging capacity of different concentrations of aqueous,methanolic and dichloromethane leaf extracts of Momordica foetida Schumach. et Thonn.and the ability of these extracts to inhibit in vitro plasma lipid peroxidation; in addition,healthy human adipose mesenchymal stem cell cultures were used in order to test the hypothesis that these extracts may affect adipocyte differentiation. Results obtained in thisstudy suggested that aqueous extract might be useful in preventing metabolic syndrome.
2013
Momordica foetida Schumach. et Thonn.,; antioxidant activity,; adipogenic differentiation
File in questo prodotto:
File Dimensione Formato  
Molecules 2013- .pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 333.54 kB
Formato Adobe PDF
333.54 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/619
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 19
social impact