It is generally accepted that lipid peroxides play an important role in the pathogenesis of free radical-induced cellular injury and that endogenous thiols are vital in cellular defense against oxidative stress. The purpose of this work was to investigate the effect of oxidative stress on the synthesis of heat shock protein HSP70 in absence and presence of lipoic acid as an antioxidant. The interested observation emerging from this study was the marked correlation between oxidative stress and induction of HSP 70 which was found in primary cultures of normal human skin fibroblasts. Our finding suggest a correlation between mechanisms of oxidative stress, antioxidants and HSP70 induction.
Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress. Relationship with the antioxidant system
Rizza V.
1998-01-01
Abstract
It is generally accepted that lipid peroxides play an important role in the pathogenesis of free radical-induced cellular injury and that endogenous thiols are vital in cellular defense against oxidative stress. The purpose of this work was to investigate the effect of oxidative stress on the synthesis of heat shock protein HSP70 in absence and presence of lipoic acid as an antioxidant. The interested observation emerging from this study was the marked correlation between oxidative stress and induction of HSP 70 which was found in primary cultures of normal human skin fibroblasts. Our finding suggest a correlation between mechanisms of oxidative stress, antioxidants and HSP70 induction.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
